The Evolving Landscape of Cold Stored Platelets

Continuing Education Credits

• P.A.C.E.® Contact Hours: 1.5 hour(s)
• Florida Board of Clinical Laboratory Science CE Credit Hours -
  General (Blood Banking / Immunohematology): 1.5 hour(s)

Objectives

• Identify the key advantages of cold-stored platelets over conventionally stored platelets, including extended shelf life and reduced risk of bacterial contamination.
• Recognize the limitations associated with cold storage methods for platelets, such as potential alterations in platelet function and activation during storage.
• Describe the impact of cold storage on platelet viability, function, and hemostatic properties, and its implications for transfusion efficacy.
• Evaluate the clinical implications of using CSPs for acute trauma patients with severe bleeding, patients undergoing high-risk surgeries, neonates and pediatric patients, and other relevant patient populations.
• Analyze the logistical considerations for implementing cold storage technology for platelets within blood bank facilities or hospital transfusion services.

Course Outline

• Introduction
• Introduction
• Key Terms
• Current Practice of Room Temperature Platelets
• Current Practice and a Look to the Future
• The History that Led to Current Practice
• The New England Journal of Medicine - 1969
• The Journal of Clinical Investigation - 1971
• Advantages of Room Temperature Platelets
• Disadvantages of Room Temperature Platelets
• Platelet Storage Lesion
• Platelet Storage Lesion, continued
• Which of the following is a key advantage of storing platelets at room temperature?
• Which of the following is the primary reason for the limited shelf life of room temperature platelets (RTPs)?
• Cold-Stored Platelets
• Re-Introducing Cold-Stored Platelets
• Advantages of Cold-Stored Platelets
• Disadvantages of Cold-Stored Platelets
• Which of the following is a primary advantage of extended shelf life in cold-stored platelets (CSPs)?
• A potential concern regarding the widespread implementation of cold-stored platelets (CSPs) is:
• Cold-Stored Platelet Viability
• Impact of Cold Storage on Platelet Viability: Metabolic Suppression
• Impact of Cold Storage on Platelet Viability: Mitochondrial Dysfunction
• Which of the following is a primary consequence of the metabolic slowdown induced by cold storage in platelets?
• Cold storage can affect mitochondrial function in platelets by:
• Cold-Stored Platelet Function
• Impact of Cold Storage on Platelet Function: Aggregation
• Impact of Cold Storage on Platelet Function: Activation
• Impact of Cold Storage on Platelet Function: Granules
• Which of the following changes in cold-stored platelets (CSPs) contributes to their enhanced aggregation potential?
• A structural change in cold-stored platelets (CSPs) that mimics the initial stage of platelet activation is:
• Which of the following substances, stored within platelet granules, plays a crucial role in promoting blood vessel narrowing (vasoconstriction)?
• Cold-Stored Platelets and Bleeding Risk
• Cold-Stored Platelets and Bleeding Risk
• Which of the following is a potential way cold-stored platelets (CSPs) could contribute to increased bleeding risk?
• A patient with which of the following conditions might be at a higher risk for complications when receiving cold-stored platelets (CSPs)?
• Cold-Stored Platelets and Transfusion Practice
• Trauma and Active Bleeding
• Challenges of Traditional Platelet Supply
• Surgical Procedures
• A potential advantage of using cold-stored platelets (CSPs) in a trauma patient with severe bleeding is:
• A primary reason why maintaining consistent platelet supplies in remote locations is difficult with room temperature platelets (RTPs) is:
• A potential advantage of using cold-stored platelets (CSPs) during surgery is:
• Research and Clinical Implementation
• Current Clinical Trials
• Regulatory Hurdles and Approval
• Logistics and Cost Effectiveness
• A primary goal of current clinical trials on cold-stored platelets (CSPs) is to determine if they:
• To gain regulatory approval for widespread use, cold-stored platelets (CSPs) must demonstrate:
• Specific Patient Populations
• Cold-Stored Platelets in Neonates and Pediatrics
• Cold-Stored Platelets in Patients with Bleeding Disorders
• Cold-Stored Platelets in Thrombocytopenia
• A potential advantage of using cold-stored platelets (CSPs) in neonates and children is:
• What is the potential benefit of using cold-stored platelets (CSPs) in patients with bleeding disorders?
• Thrombocytopenia, a condition crucial to the potential use of cold-stored platelets (CSPs), is characterized by:
• Future Directions
• Rejuvenation Techniques
• Optimizing Storage Solutions
• The Ethics of Cold-Stored Platelet Adoption
• A potential rejuvenation strategy for cold-stored platelets involves:
• A primary goal of optimizing storage solutions for cold-stored platelets (CSPs) is to:
• The Future of Transfusion Medicine
• The Future of Transfusion Medicine
• References
• References

Additional Information