Myeloproliferative Neoplasms

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Author: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)
Reviewer: Rebecca J. Laudicina, PhD, MLS(ASCP)CM & Laurie Bjerklie, MA, MLS(ASCP)CM

This course describes the 2008 World Health Organization classification system for myeloproliferative neoplasms (MPNs). The different types of MPNs are compared and contrasted based upon etiology and patient symptoms. Hematologic, cytogenetic, and other laboratory features associated with specific MPNs are presented in this course along with a list of common treatment options.

Continuing Education Credits

Objectives

  • Describe the World Health Organization classification system for myeloproliferative neoplasms (MPNs).
  • Compare and contrast the types of MPNs based upon etiology and patient symptoms.
  • Discuss the hematologic, cytogenetic, and other laboratory features associated with specific MPNs.
  • List common treatment options.

Course Outline

  • Myeloproliferative Neoplasms
      • Introduction to Myeloproliferative Neoplasms (MPNs)
      • Classification of Myeloproliferative Neoplasms (MPNs)
      • Pathophysiology of Myeloproliferative Neoplasms (MPNs)
      • Symptoms
      • Match the myeloproliferative neoplasm with the cell line that is most affected.
    • Chronic Myeloid Leukemia
      • Chronic Myeloid Leukemia (CML)
      • CML and the Philadelphia Chromosome
      • Laboratory Investigation of CML
      • CML Peripheral Blood Smear
      • Progression of CML
      • Treatment of CML
      • The Philadelphia chromosome, associated with chronic myeloid leukemia (CML), involves a reciprocal translocation of genes from which two chromosomes?
    • Chronic Neutrophilic Leukemia
      • Chronic Neutrophilic Leukemia (CNL)
      • Chronic Neutrophilic Leukemia (CNL), continued
    • Hypereosinophilic Syndrome/Chronic Eosinophilic Leukemia
      • Hypereosinophilic Syndrome (HES)
      • Chronic Eosinophilic Leukemia (CEL)
      • What causes the characteristic heart and/or lung damage frequently demonstrated in patients with chronic eosinophilic leukemia?
    • Essential Thrombocythemia
      • Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocythemia (ET)
      • Diagnosis of Essential Thrombocythemia (ET): Bone Marrow Findings
      • Essential Thrombocythemia (ET) Diagnosis
      • ET Treatment
      • Which thrombocytic characteristic is not associated with essential thrombocythemia (ET)?
    • Primary Myelofibrosis
      • Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis (PMF)
      • Diagnosis of Primary Myelofibrosis: World Health Organization (WHO) Criteria
      • Treatment of Primary Myelofibrosis (PMF)
      • Which red blood cell morphologic feature is associated with primary myelofibrosis?
    • Polycythemia Vera
      • Polycythemia Vera (PV)
      • Diagnosis of Polycythemia Vera (PV)
      • Treatment of Polycythemia Vera
      • The primary WHO criteria for diagnosis of polycythemia vera are bone marrow morphology (hypercellularity with prominent erythroid, granulocytic, and m...
    • Myeloproliferative Neoplasm, Unclassifiable (MPN-u)
      • Myeloproliferative Neoplasms, Unclassifiable (MPN-u)
  • Summary
      • Laboratory Findings Associated with Myeloproliferative Neoplasms (MPNs)
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.
 
Author information:  Leah Coppolino, MPH, MLS(ASCP)CM is a Program Director at MediaLab, Inc. Previously, she was the Director of the Medical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.
 
Reviewer information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous hematology-related publications.
 
Reviewer information: Laurie Bjerklie, M.A., MLS(ASCP)CM is currently a Content Developer for MediaLab and LabCE. She earned a B.S. in Medical Laboratory Science from the University of North Dakota and an M.A. in Curriculum and Instruction from Saint Xavier University. She has over 14 years of experience in higher education and has held faculty positions in both MLT and MLS programs. She most recently served as the Program Manager of Medical Laboratory Science at Saint Louis University.

This course is part of:
Therapeutic phlebotomy from ITxM Diagnostics website with permission 8/2014 LC
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