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GP IIb/IIIa Inhibitors
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GP IIb/IIIa Inhibitors
Examples:
Abciximab
,
eptifibatide
, and
tirofiban
are examples of drugs in this medication class.
Mechanism of action:
Glycoprotein IIb/IIIa (GP IIb/IIIa) receptors exist on the surface of platelets. In the normal clotting process, a fibrin molecule will attach to the GP IIb/IIIa receptor on two neighboring platelets, linking them together. These drugs function to block the GP IIb/IIIa sites and prevent fibrin from binding to platelets in the clot formation process.
Use:
The drugs in this class are especially useful after a patient has undergone coronary angioplasty, a procedure in which occluded arteries of the heart are opened.
Laboratory measurement:
Laboratory measurement of these drugs is not routine, as they are usually given only for a short amount of time. They are often used with heparin during coronary angioplasty procedures.
Toxicity:
Bleeding and allergic reactions are a risk with these drugs. Thrombocytopenia has also been noted with this class of medication.
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