Table: Additional Testing That May Be Ordered for Acute (Immediate) Transfusion Reaction Investigations

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Table: Additional Testing That May Be Ordered for Acute (Immediate) Transfusion Reaction Investigations

The table below lists the reaction types that were previously described and summarizes additional testing that may be ordered.
Table 2: Additional Testing
Acute Reaction Type
Additional Testing
Anaphylactic
  • Anti-IgA
  • IgA quantitative
Febrile nonhemolytic
  • If initial testing is negative, perform a culture to rule out a bacterially-contaminated blood component.
  • When other sources of the fever have been ruled out, the reaction is categorized as a febrile nonhemolytic transfusion reaction (FNHTR).
Hemolytic
  • Bilirubin
  • Haptoglobin
  • Lactate dehydrogenase (LDH)
Transfusion-associated bacterial sepsis
  • Gram stain
  • Culture of component
  • Blood culture of the recipient
Transfusion-associated circulatory overload (TACO)
  • Chest x-ray
  • B-type natriuretic peptide (BNP)
Transfusion-related acute lung injury (TRALI)
  • Chest x-ray
  • BNP
  • Leukocyte antibody screens (donor and recipient plasma)
  • Antigen typing of recipient