Acquired Coagulation Disorders

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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Acquired Coagulation Disorders

A lack of Vitamin K can cause a loss of functionality in Vitamin K-dependent coagulation factors, specifically, factors II, VII, IX, and X. Most often associated with a diet lacking in Vitamin K, it may also present in situations of broad-spectrum antibiotic use, where normal flora in the gut have been eliminated.

As one might expect, treatment involves a diet rich in Vitamin K-containing foods and judicious use of broad-spectrum antibiotics.
Note: The Vitamin K-dependent coagulation factors are also known as the Prothrombin group.