Sickle Cell Disorder Frequency: Hb S / Thalassemia - LabCE.com, Laboratory Continuing Education

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Sickle Cell Disorder Frequency: Hb S / Thalassemia

Hb S / thalassemia combination	Affected populations	Severity	Comments
Hb S beta thalassemia	North Africa, India, and the Mediterranean region, especially Greece and Turkey.	Varies	Hb S beta-plus thalassemia, type 1 and Hb S beta-minus thalassemia need supportive therapy and may have severe anemia Hb S beta-plus thalassemia, type 2 requires very little medical attention
Hb SA alpha-plus thalassemia	Common in persons of African ancestry	Usually asymptomatic	Less hemoglobin S produced than in persons with Hb S trait
Hb SS-alpha thalassemia (either plus or zero)	African and Mediterranean ancestry	Mild anemia midway in severity between sickle cell disease and trait	Produce increased levels of Hb F in proportion to the number of alpha gene deletions present. This acts to retard the sickling process.